diazepam will increase toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Keep an eye on Closely. Scientific studies have shown that the combination of benzodiazepines and buprenorphine altered the standard ceiling impact on buprenorphine-induced respiratory despair, building the respiratory outcomes of buprenorphine look much like These of whole opioid agonists.

Diazepam is often a Timetable IV controlled substance with the prospective for abuse. Development of dependence and tolerance can take place in dependancy-vulnerable, long-term treatment or Those people people having superior doses. So, these men and women really should be beneath cautious supervision; as soon as a person develops dependence, the chance of creating withdrawal signs and symptoms raises.

Use Warning/Keep an eye on. Ethinyl estradiol could inhibit the clearance of benzodiazepines that go through oxidation, therefore rising serum concentrations of concomitantly administered benzodiazepines.

benzhydrocodone/acetaminophen and diazepam the two enhance sedation. Stay away from or Use Alternate Drug. Restrict use to sufferers for whom substitute treatment method possibilities are inadequate

Keep an eye on Intently (1)ethinylestradiol will enhance the level or effect of diazepam by System: decreasing metabolism.

Concomitant use of benzodiazepines and opioids may well cause profound sedation, respiratory despair, coma, and Loss of life

bosentan will lessen the level or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

Usage of benzodiazepines, together with diazepam, the two used by yourself and together with other CNS depressants, might result in possibly fatal respiratory depression

This is not a whole list of probable Uncomfortable side effects. When you discover other consequences not stated higher than, Get hold of your medical doctor or pharmacist.

cannabis will boost the amount or result of diazepam by click here impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

If it's not possible, give drug into tubing of a flowing IV solution as near as feasible to vein insertion

If any withdrawal reaction develops, think about pausing taper or growing dose to past tapered dosage degree; subsequently decrease dose far more bit by bit

Because diazepam and its metabolites may very well be present in human breast milk for extended periods of time following acute use, people needs to be advised not to breastfeed for an ideal time frame following obtaining remedy

Observe Closely (1)triclabendazole will increase the degree or influence of diazepam by influencing hepatic enzyme CYP2C19 metabolism.